Every effort has been made to ensure the accuracy of the Phenylpropanolamine Chewable Tablets (50 mg) information published above. Diethylstilbestrol (DES) is a nonsteroidal estrogen derivative that closely resembles the natural estrogen, estradiol. PPA should be avoided or used with caution in dogs with glaucoma, cardiovascular disease, hypertension, renal insufficiency, and diabetes mellitus. Possible side effects include restlessness, CNS excitation, irritability, tachycardia, hypertension, and anorexia. There is limited information on the toxic dose of ephedrine Ephedrine. Previously available in over-the-counter cold medications and appetite suppressants, it was withdrawn from the human market because of toxicity associated with overuse as a diet aid. DES is given as a daily loading dose for 7–10 days and then reduced to once weekly dosing, if possible, to avoid toxicity. It is still available for veterinary use in dogs, however, as a treatment for urinary incontinence. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world. Ephedrine, pseudoephedrine, or phenylephrine may be tried but are less efficacious than PPA. Effect of hormones on urethral sensitivity to phenylephrine in normal and incontinent dogs. Keep container tightly closed. Reduced urethral sphincter tone may result in urinary incontinence, a condition seen in primarily in ovariohysterectomized bitches but also in aged, obese bitches and occasionally in neutered male or intact dogs. Pupil dilation is performed during some portions of an eye examination. Estrogens sensitize the urethral sphincter to α-adrenergic stimulation; therefore, DES therapy is synergistic with α-adrenergic drugs. Although often more clinically effective than DES, their action is short lived, usually requiring dosing bid-tid. Phenylephrine may also be used with other drugs such as atropine , to … Decongestants work by constricting (or tightening) the blood vessels in the nose (and the rest of the body). 1. DES continues to be available to patients through compounding pharmacies ; however, estriol has since received FDA approval and represents a new way to use estrogens for sphincter incontinence in female dogs. Dog incontinence is a health condition that occurs more frequently in older dogs, even though there are other factors that may lead to involuntary urination. Phenylephrine is in most decongestants, including Sudafed, and dogs don’t handle it well. Of this class of drugs, PPA is the most effective and results in fewer cardiovascular adverse effects. Please refer to the following dosage charts: * Veterinarian may compound the drug for patients weighing 7 lb and under. The most common cause of urinary incontinence is weak urethral musculature. Phenylephrine Phenylephrine is less of a risk due to low oral bioavailability. PPA 50 mg tablets are available in 60 count and 180 count bottles. Phenylephrine HCl, commonly known as Ak-Dilate® or Ak-Nephrin®, is an agent used to dilate the pupil in dogs and cats. The dose and frequency needed for each animal tend to vary widely and may need to be increased over time to maintain continence (Table 1). Monitor Your Buddy We comply with the HONcode standard for trustworthy health information -, Phenylpropanolamine Chewable Tablets (50 mg) Indications, Warnings and cautions for Phenylpropanolamine Chewable Tablets (50 mg), Direction and dosage information for Phenylpropanolamine Chewable Tablets (50 mg). Author links open overlay panel K.E. Sudafed Pseudoephedrine is a decongestant found in many cold remedies, but acts like a stimulant in dogs, who can experience elevated heart rates and seizures. NADA# 141-324 Phenylpropanolamine is an α- and β-adrenergic agonist that stimulates smooth muscle contraction of the internal urethral sphincter, increasing urethral sphincter tone and closure of the bladder neck. Available for Android and iOS devices. Phenylpropanolamine (PPA) (Proin, prnpharmacal.com) is the most widely used α-agonist for the treatment of UI. Creed KE. Is your dog already exhibiting any of the above symptoms? Adverse reactions related to administration of PPA may include restlessness, excitation, irritability, tachycardia, hypertension, vomiting, and anorexia. Each Phenylpropanolamine (PPA) chewable tablet contains 50 mg of phenylpropanolamine hydrochloride. Effect of hormones on urethral sensitivity to phenylephrine in normal and incontinent dogs. Incontinence often occurs in middle aged or older spayed female dogs. For respiratory symptoms, the dosage in dogs is 0.1 to 0.2 mg per pound (0.2 to 0.4 mg/kg) or 15 to 60 mg per dog by mouth every 8 to 12 hours. It is most common in large breed, spayed female dogs (11%–20% incidence) but may be seen in intact females, male dogs, and cats. It works by reducing swelling of the nasal passages. Human Warnings: Not for human use. In male dogs, testosterone injections are used to treat urinary incontinence but are generally less effective than estrogen therapy in female dogs. In male dogs, testosterone injections are used to treat urinary incontinence but are generally less effective than estrogen therapy in female dogs. Not for human use. Store at controlled room temperature. Data sources include IBM Watson Micromedex (updated 2 Feb 2021), Cerner Multum™ (updated 3 Feb 2021), ASHP (updated 29 Jan 2021) and others. Many Prescription Medications Dosage may be rounded to the nearest 12.5 mg (1/4 tablet) for practical dosing. increased dog urethral sensitivity to alpha-adrenergic agonists, such as phenylephrine. The originating document has been archived. Manufactured by Neogen Corporation, Lexington, KY 40511, Copyright © 2021 Animalytix LLC. Please confirm that you are a health care professional. The link you have selected will take you to a third-party website. In cats, it is dosed at 0.5 mg per pound (1 mg/kg) orally every 8 hours. It is orally bioavailable and reaches peak plasma concentrations in 1 hr in dogs; it has an elimination half-life of 24 hr because of enterohepatic recirculation. Keep the dog's private areas clean. Urinary incontinence most commonly affects spayed, female dogs but can develop in any individual. Other adverse effects seen in dogs include alopecia, cystic ovaries, cystic endometrial hyperplasia, pyometra, prolonged estrus, and infertility. Which of the following intravenous diuretics is the most appropriate treatment for life-threatening pulmonary edema caused by CHF? Dogs: 0.1–0.3 mg/kg/day, PO, for 7–10 days, followed by 1 mg/dog/wk, Dogs: 1.5–2 mg/kg, PO, once to three times daily. 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